Premature babies that need ventilation to support their breathing often suffer from a condition known as bronchopulmonary dysplasia. Researchers have now discovered a molecular mechanism that plays a key role in the development of the disease.
Increased arterial stiffness is a known predictor of cardiovascular diseases in different populations, including healthy subjects and patients with hypertension, diabetes, or renal disease. A new study examining arterial stiffness in a large population determined that both restrictive spirometry pattern and reduced forced vital capacity (FVC) were associated with a higher risk of arterial stiffness not only in men but also in women. The investigators found that arterial stiffness increased fourfold when FVC decreased.
Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease severity in people with chronic bronchitis. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.