Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent study, researchers revealed the three-dimensional structure of one of these proteins, beta-Klotho, illuminating its intricate mechanism and therapeutic potential.
In Switzerland, 5,500 operations to combat morbid obesity are conducted every year. Gastric bypasses and sleeve gastrectomy operations perform similarly: patients lose two-thirds of their excess weight in the long term. When it comes to gastric acid reflux, the bypass clearly shows better results.
With medical advances and efforts to curb smoking, one might expect that US life expectancy would improve. Yet there's been a reduction in the rate of improvement in American mortality during the last three decades.Researchers say a rise in obesity is to blame, slowing declines in death rates by a half-percentage point per year. The scientists estimate that rising obesity was about twice as important for mortality trends as a decline in smoking.
Obese, middle-age men and women who had bariatric surgery have half the death rate of those who had traditional medical treatment over a 10-year period, reports a study that answers questions about the long-term risk of the surgery. Previous studies looking at this question were indefinite because follow-up data was limited due to high costs and patients dropping out.
Researchers have shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.
It is well known that healthy eating increases our general sense of wellbeing. Researchers have now discovered that a fiber-rich diet can have a positive influence on chronic inflammatory joint diseases, leading to stronger bones.
The immune system reacts similarly to a high fat and high calorie diet as to a bacterial infection. Unhealthy food seems to make the body's defenses more aggressive in the long term. Even long after switching to a healthy diet, inflammation towards innate immune stimulation is more pronounced. These changes may be involved in the development of arteriosclerosis and diabetes.
An analysis of published studies indicates that following the Mediterranean diet may reduce the risk of frailty in older individuals. The findings suggest that a diet emphasizing primarily plant-based foods -- such as fruits and vegetables, whole grains, legumes, and nuts -- may help keep people healthy and independent as they age.
New research in mice and humans suggests that an enzyme called SNRK suppresses inflammation in obesity-related 'white fat' while increasing metabolism in heat-producing 'brown fat,' making SNRK an intriguing target in the battle against obesity.
Researchers determined that men who followed a Mediterranean diet, rich in fish, boiled potatoes, whole fruits, vegetables, legumes, and olive oil, and low consumption of juices had lower risk of aggressive prostate cancer (PC) than those who followed other dietary patterns like Prudent or Western diets.
We may have a new reason, in addition to vitamin D generation, to bask in a little sunshine. A breakthrough has shown the fat cells that lie just beneath our skin shrink when exposed to the blue light emitted by the sun.