Thursday, 14 December 2017
News with tag Scientists  RSS
A metallopeptide targets and disrupts mitochondrial function in breast cancer stem cells

Added: 14.12.2017 6:12 | 0 views | 0 comments

Killing malignant mitochondria is one of the most promising approaches in the development of new anticancer drugs. Scientists have now synthesized a copper-containing peptide that is readily taken up by mitochondria in breast cancer stem cells, where it effectively induces apoptosis. The study also highlights the powerful therapeutic potential of the metallopeptides.

From: feeds.sciencedaily.com

Tasmanian tiger was 'doomed by poor DNA' long before it was wiped out by hunting, scientists say

Added: 14.12.2017 6:07 | 0 views | 0 comments


Scientists in Australia have mapped the genetic sequence of the extinct Tasmanian tiger, raising hopes of reviving the species, whose last survivor died in a zoo in the city of Hobart in September 1936. The landmark study of the Tasmanian tiger, or thylacine, was based on examination of DNA from a female pup that had been preserved in ethanol at a museum since 1909. Andrew Pask, a researcher from the University of Melbourne, said that establishing a blueprint of the thylacine’s entire genetic code was the first step in trying to bring back the species through cloning. “As this genome is one of the most complete for an extinct species, it is technically the first step to ‘bringing the thylacine back’,” he said.  “We are still a long way off that possibility. We would need to develop a marsupial model to host the thylacine genome, like work conducted to include mammoth genes in the modern elephant.” Tasmanian tigers became extinct on the Australian mainland about 3,000 years ago but survived on the island state of Tasmania. The species was hunted by European settlers who believed the animals threatened their sheep and who were encouraged by a government bounty of £1 per carcass. Tasmanian tigers or thylacines photographed at Beaumaris Zoo in Hobart in Australia's Tasmania state in 1918 Credit:  AFP / TASMANIAN MUSEUM AND ART GALLERY The last known creature died in captivity in 1936, though the species was not officially declared extinct until 1982. But the genome study revealed that the sandy-coloured marsupial may have become extinct even if humans had not settled in Tasmania. The sequencing found that the thylacine had little genetic diversity, making it harder for it to survive changes in environmental conditions. "They were actually in pretty bad genetic shape and it wasn't because of their isolation on Tasmania. It was a longer-term decline in their history," Dr Pask said. “We certainly made them go extinct — there's no question about that. But we now know even if [thylacines] were still around today they'd probably be in the same genetic dire circumstances as the Tasmanian devil [a local species that is under threat]." The Tasmanian tiger has a somewhat mythical status in Australia and there is still frenzied speculation about whether it may have survived in the wild. There have been regular reported sightings, though most experts believe that the creatures that are spotted are probably feral dogs and that the thylacine is unlikely to have survived. Recent unconfirmed sightings in the state of Queensland prompted a fresh search which has so far proven fruitless. The study found that the genetic health of the thylacine became compromised about 70,000 to 120,000 years ago, an era which coincided with an ice age. The Tasmanian species became  isolated when the island was cut off from the mainland due to rising seas about 14,000 years ago. On the mainland, the species became extinct due to extreme weather and drought, according to a study released earlier this year. Experts said it could take some years – and billions of dollars - to revive the species. "We still have a way to go to get the technology and to get that at a reasonable cost," Christy Hipsley, from Museums Victoria, told Channel Seven. However, Dr Pask said he believed humans have a moral obligation to try to revive the species. "I think we were responsible for hunting [the species] to extinction - in that case, we almost owe it to the species to bring it back," he said. The findings were published in the journal Nature Ecology and Evolution.

A metallopeptide targets and disrupts mitochondrial function in breast cancer stem cells

Added: 14.12.2017 5:24 | 0 views | 0 comments

Killing malignant mitochondria is one of the most promising approaches in the development of new anticancer drugs. Scientists have now synthesized a copper-containing peptide that is readily taken up by mitochondria in breast cancer stem cells, where it effectively induces apoptosis. The study also highlights the powerful therapeutic potential of the metallopeptides.

Scientists call for improved technologies to save imperiled California salmon

Added: 14.12.2017 3:58 | 0 views | 0 comments

Scientists working to protect California's most endangered salmon say that key improvements in tracking Sacramento River winter-run Chinook through California's complex water delivery system would help recover the species while the water continues to flow.

From: https:

Giant Penguin: This Ancient Bird Was As Tall As a Refrigerator

Added: 14.12.2017 3:06 | 0 views | 0 comments

The fossils of a refrigerator-size penguin were so gargantuan that the scientists who discovered them initially thought they belonged to a giant turtle. The ancient behemoth is now considered the second-largest penguin on record.

From: https:

Scientists call for improved technologies to save imperiled California salmon

Added: 14.12.2017 3:01 | 0 views | 0 comments

Scientists working to protect California's most endangered salmon say that key improvements in tracking Sacramento River winter-run Chinook through California's complex water delivery system would help recover the species while the water continues to flow.

From: feeds.sciencedaily.com

Hurricane Harvey rainfall 'weighed 127bn tonnes'

Added: 14.12.2017 2:14 | 1 views | 0 comments

Scientists established how much rain fell by measuring how much the Earth compressed during the storm.

From: www.bbc.co.uk

How Greenland would look without its ice sheet

Added: 14.12.2017 0:52 | 0 views | 0 comments

Scientists stitch together decades of survey data to reveal a hidden world of mountains and canyons.

From: www.bbc.co.uk

Scientists to investigate if cigar-shaped asteroid could be an alien spacecraft

Added: 14.12.2017 0:12 | 0 views | 0 comments


A team of researchers, including Stephen Hawking, is investigating whether the first known object from outside the solar system contains the first sign of life beyond our planet.

From: https:

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